Quantification of Maternal Serum Cell-Free Fetal DNA in Early-Onset Preeclampsia
نویسندگان
چکیده
منابع مشابه
Quantification of Maternal Serum Cell-Free Fetal DNA in Early-Onset Preeclampsia
The aim of this study was to determine whether the increased serum cell-free fetal DNA (cffDNA) level of gravidas developed into early-onset preeclampsia (EOPE) subsequently in the early second trimesters is related to prenatal screening markers. Serum was collected from 1011 gravidas. The level of cffDNA and prenatal screening markers were analyzed in 20 cases with EOPE and 20 controls. All fe...
متن کاملQuantitative abnormalities of fetal DNA in maternal serum in preeclampsia.
BACKGROUND There is much recent interest in the biologic and diagnostic implication of cell-free non-host DNA in the plasma and serum of human subjects. To determine if quantitative abnormalities of circulating non-host DNA may be associated with certain pathologic processes, we used circulating fetal DNA in preeclampsia as a model system. METHODS We studied 20 preeclamptic women and 20 contr...
متن کاملApplications of Cell-Free Fetal DNA in Maternal Serum
Cell-free fetal DNA (cffDNA) is available in the maternal circulation throughout pregnancy and can be used for noninvasive prenatal diagnosis including, determination of fetal sex, identification of specific single gene disorders, typing of fetal blood groups (RhD), paternity determination and potentially routine use for Down’s syndrome (DS) testing of all pregnancies. I searched published lite...
متن کاملMaternal and Neonatal Outcomes in Expectant Management of Early-Onset Severe Preeclampsia
Background and Objective: Preeclampsia is one of the most critical complications of pregnancy observed in 2%-8% of all pregnancies. Severe preeclampsia has many maternal and neonatal complications that are more prevalent in early-onset preeclampsia. The present study aimed to determine the prevalence of maternal and neonatal outcomes of expectant management of severe preeclampsia before 34 week...
متن کاملO-45: Quantification of Cell-Free-Fetal-DNAfrom Maternal Plasma for the First Time in Pakistan:Diagnosis of Genetic Disorders
Background: Current prenatal diagnosis requires invasive testing which carries a 1-4% procedure-related-risk of miscarriage; hence, non-invasive techniques are desired. The recent demonstration of cell-free-fetal-DNA enriched from maternal plasma has opened new possibilities for non-invasive-prenatal-diagnosis of not only genetic-disorders such as β-thalassaemia and haemophilia but also chromos...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2013
ISSN: 1422-0067
DOI: 10.3390/ijms14047571